Journal of Pediatric Research and Neonatal Care
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Noteworthy Reductions in Catheter-Related Bloodstream Infections among Neonates: A Detailed Analysis
Luciano Mantovani1*, Luigi Nigri2
1Postgraduate Pediatric Residency Program, Residents Committee, University of Foggia, Foggia, Italy
2Undergraduate School, Bachelor Course in Economics, Management and Finance, Bocconi University, Milan, Italy
Abstract
The colonization of intravascular catheters, leading to subsequent bloodstream infections, is a common cause of nosocomial infections in newborns. This study aimed to assess the microbial colonization of intravascular catheters in newborns admitted to the Special Care Baby Unit (SCBU) at a 550-bed Children's Hospital in Mandalay during the period from January to September 2015. A total of 84 newborns, with or without clinical sepsis, were selected for the study. The intravascular catheters were cultured using a semi-quantitative (roll plate) method. Additionally, peripheral blood samples were collected from 35 patients with clinical sepsis and intravascular catheters for conventional culture. Antimicrobial susceptibility testing was conducted following CLSI guidelines.
Microbial colonization occurred in 17.9% (15/84) of cases, with no instances of catheter-related bloodstream infection (CRBSI) identified. The predominant microorganism was coagulase-negative staphylococci (CoNS) in 53.3%, followed by Staphylococcus aureus (33.3%), Enterococcus species (6.7%), and Enterobacter species (6.7%). Methicillin resistance was observed in 25% of CoNS, and methicillin-resistant Staphylococcus aureus (MRSA) was present in 80% of the Staphylococcus aureus isolates. Isolated Enterococcus species exhibited resistance to cloxacillin and oxacillin, while Enterobacter species were resistant to gentamicin and cefotaxime. This study highlights the occurrence of microbial colonization on intravascular catheters in newborns, along with the susceptibility patterns of the identified microorganisms. The findings contribute valuable insights for pediatricians in antibiotic selection and offer practical healthcare guidance for controlling nosocomial bloodstream infections.
