Journal of Immunology Research and Infectious Diseases

A New Therapeutic Target Against HIV/AIDS Virion Proteins Stimulation by Cells Exposed

Marie V Miller*, Engels Kwong

Forum for Collaborative HIV Research, School of Public Health, University of California Berkeley, USA

Abstract

Background: The pathologic process and response to a chronic infection is varied particularly for HIV infection. The impact of HIV on the general immune environment of the infected individual is profound and triggered by multiple stimuli. whereas replication competent infection induces an oversized spectrum of immune responses, like protein unharness, we tend to be targeted on what happens once cells are exposed to replication incompetent virions and their parts.

Results: observation the cytokines free from lymph cell lines exposed to HIV particle parts, we tend to find many cytokines were upregulated with IL-16 being the foremost upregulated. HIV particle parts evoked Caspase-3 activation that is needed for IL-16 unharness and this IL-16 unharness relies on macromolecule parts inside the HIV particle.

Conclusion: Overall, this work permits United States to envision that replication incompetent HIV virions have a bearing on the immune landscape of an individual infected by HIV. specifically, we tend to see that exposure of T cells to HIV particle proteins ends up in Caspase-3 activation and ensuant IL-16 unharness.

Keywords:

HIV; AIDS; Innate Immunity; Cytokines, Cytokine; Array; IL-16; Caspase-3